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Amlodipine may increase the risk of worsening angina or acute myocardium infarction, especially in those with severe obstructive coronary artery disease, upon dosage initiation or increase. Mianserin may enhance the sedative effects of drugs such as alcohol, anxiolytics, hypnotics, or antipsychotics when co-administered. Reproductive sexual intercourse between non-human animals is more often called copulation, and sperm may be introduced into the female's reproductive tract in non-vaginal ways among the animals, such as by cloacal copulation. AD-1211 is an opioid analgesic drug invented in the 1970s by Dainippon Pharmaceutical Co. When she refuses to do so, he has her son Daniel kidnapped. This finding indicates that GBL is a naturally occurring component in some wines and may be present in similar products. The bottom-up pathway represents the leverage point for pharmaceutical interventions. 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